Immunoreactivity to metal and silica associates with sarcoidosis in Dutch patients (2024)

Beijer, E., Meek, B., Bossuyt, X., Peters, S., Vermeulen, R. C. H., Kromhout, H., & Veltkamp, M. (2020). Immunoreactivity to metal and silica associates with sarcoidosis in Dutch patients. Respiratory Research, 21(1), 1-8. Article 141. https://doi.org/10.1186/s12931-020-01409-w

Beijer, E ; Meek, B ; Bossuyt, X et al. / Immunoreactivity to metal and silica associates with sarcoidosis in Dutch patients. In: Respiratory Research. 2020 ; Vol. 21, No. 1. pp. 1-8.

@article{b21cacaab1b3435ab10c41b4a004a5e4,

title = "Immunoreactivity to metal and silica associates with sarcoidosis in Dutch patients",

abstract = "BACKGROUND: Involvement of metals or silica in the pathogenesis of sarcoidosis has been suggested by several case reports and specific epidemiological studies. However, the combination of occupational exposure and an immunological reaction has not been studied before in a group of sarcoidosis patients and non-sarcoidosis controls.METHODS: In 256 sarcoidosis patients and 73 control patients with obstructive sleep apnea, exposure to metal and silica was assessed using a questionnaire consisting of a complete occupational history subsequently linked to job-exposure matrices. Next, immunoreactivity to aluminium, beryllium, zirconium and silica was determined in 33 sarcoidosis and 19 control patients using a lymphocyte proliferation test.RESULTS: In sarcoidosis, 83 out 256 patients (32.4%) had occupational exposure to metals or silica, compared to 24.7% in the control group (p = 0.21). A significantly higher percentage of the sarcoidosis patients tested showed immunoreactivity to metals or silica compared to the control group (21.2 and 0% respectively, p = 0.039).CONCLUSIONS: Immunoreactivity to silica and metals was only found in sarcoidosis patients, supporting the hypothesis that these antigens may be involved in the pathogenesis of a distinct subgroup of sarcoidosis patients. This indicates that when searching for causative agents in sarcoidosis patients, besides beryllium, also zirconium, aluminium and silica deserve clinical investigation.",

keywords = "Sarcoidosis, Aluminium, Beryllium, Zirconium, Metals, Silica",

author = "E Beijer and B Meek and X Bossuyt and S Peters and Vermeulen, {R C H} and H Kromhout and M Veltkamp",

year = "2020",

month = jun,

day = "8",

doi = "10.1186/s12931-020-01409-w",

language = "English",

volume = "21",

pages = "1--8",

journal = "Respiratory Research",

issn = "1465-9921",

publisher = "BioMed Central",

number = "1",

}

Beijer, E, Meek, B, Bossuyt, X, Peters, S, Vermeulen, RCH, Kromhout, H & Veltkamp, M 2020, 'Immunoreactivity to metal and silica associates with sarcoidosis in Dutch patients', Respiratory Research, vol. 21, no. 1, 141, pp. 1-8. https://doi.org/10.1186/s12931-020-01409-w

Immunoreactivity to metal and silica associates with sarcoidosis in Dutch patients. / Beijer, E; Meek, B; Bossuyt, X et al.
In: Respiratory Research, Vol. 21, No. 1, 141, 08.06.2020, p. 1-8.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Immunoreactivity to metal and silica associates with sarcoidosis in Dutch patients

AU - Beijer, E

AU - Meek, B

AU - Bossuyt, X

AU - Peters, S

AU - Vermeulen, R C H

AU - Kromhout, H

AU - Veltkamp, M

PY - 2020/6/8

Y1 - 2020/6/8

N2 - BACKGROUND: Involvement of metals or silica in the pathogenesis of sarcoidosis has been suggested by several case reports and specific epidemiological studies. However, the combination of occupational exposure and an immunological reaction has not been studied before in a group of sarcoidosis patients and non-sarcoidosis controls.METHODS: In 256 sarcoidosis patients and 73 control patients with obstructive sleep apnea, exposure to metal and silica was assessed using a questionnaire consisting of a complete occupational history subsequently linked to job-exposure matrices. Next, immunoreactivity to aluminium, beryllium, zirconium and silica was determined in 33 sarcoidosis and 19 control patients using a lymphocyte proliferation test.RESULTS: In sarcoidosis, 83 out 256 patients (32.4%) had occupational exposure to metals or silica, compared to 24.7% in the control group (p = 0.21). A significantly higher percentage of the sarcoidosis patients tested showed immunoreactivity to metals or silica compared to the control group (21.2 and 0% respectively, p = 0.039).CONCLUSIONS: Immunoreactivity to silica and metals was only found in sarcoidosis patients, supporting the hypothesis that these antigens may be involved in the pathogenesis of a distinct subgroup of sarcoidosis patients. This indicates that when searching for causative agents in sarcoidosis patients, besides beryllium, also zirconium, aluminium and silica deserve clinical investigation.

AB - BACKGROUND: Involvement of metals or silica in the pathogenesis of sarcoidosis has been suggested by several case reports and specific epidemiological studies. However, the combination of occupational exposure and an immunological reaction has not been studied before in a group of sarcoidosis patients and non-sarcoidosis controls.METHODS: In 256 sarcoidosis patients and 73 control patients with obstructive sleep apnea, exposure to metal and silica was assessed using a questionnaire consisting of a complete occupational history subsequently linked to job-exposure matrices. Next, immunoreactivity to aluminium, beryllium, zirconium and silica was determined in 33 sarcoidosis and 19 control patients using a lymphocyte proliferation test.RESULTS: In sarcoidosis, 83 out 256 patients (32.4%) had occupational exposure to metals or silica, compared to 24.7% in the control group (p = 0.21). A significantly higher percentage of the sarcoidosis patients tested showed immunoreactivity to metals or silica compared to the control group (21.2 and 0% respectively, p = 0.039).CONCLUSIONS: Immunoreactivity to silica and metals was only found in sarcoidosis patients, supporting the hypothesis that these antigens may be involved in the pathogenesis of a distinct subgroup of sarcoidosis patients. This indicates that when searching for causative agents in sarcoidosis patients, besides beryllium, also zirconium, aluminium and silica deserve clinical investigation.

KW - Sarcoidosis

KW - Aluminium

KW - Beryllium

KW - Zirconium

KW - Metals

KW - Silica

U2 - 10.1186/s12931-020-01409-w

DO - 10.1186/s12931-020-01409-w

M3 - Article

C2 - 32513159

SN - 1465-9921

VL - 21

SP - 1

EP - 8

JO - Respiratory Research

JF - Respiratory Research

IS - 1

M1 - 141

ER -

Beijer E, Meek B, Bossuyt X, Peters S, Vermeulen RCH, Kromhout H et al. Immunoreactivity to metal and silica associates with sarcoidosis in Dutch patients. Respiratory Research. 2020 Jun 8;21(1):1-8. 141. doi: 10.1186/s12931-020-01409-w